The acute form occurring early after transplantation most often presents with a rash 卤 gastrointestinal symptoms and elevated liver tests. Skin biopsies, in particular, are often first used to establish the diagnosis, but interpretation must consider a number of alternative conditions related to ...
Usually the presentation of the skin rash, or the erythema, or ulcers in the mouth are generally diagnostic enough. But in certain circumstances, we do biopsies when there is a clinical differential diagnosis. Transcript edited for clarity. Case: A 49-Year-Old Man With Steroid-Refractory ...
2.Skin Rash 皮疹 3.Digestive disorders 消化道表现 4.Cytopaenia (Bone marrow suppression)血细胞...
GVHD is a known and unique complication of the allogenic SCT process. Acute GVHD, in particular, can present as a skin rash, upper/lower gastrointestinal symptoms, or liver disease. It is a result of potential tissue injury the happens from conditioning and results in increases of cytokine rele...
Grading acute graft-versus-host disease (GVHD) is usually based on quantification of rash, serum bilirubin and diarrhea. Standard criteria have been developed and used for > 20 years by most transplant centers. However, neither the standard GVHD grading system nor any of several revisions has ...
Two vaccine recipients (1.8%) developed a skin rash (one zoster-like rash with associated pain, one varicella-like) within 42 days post-vaccination that resolved with antiviral therapy. We could not confirm if these rashes were due to vaccine (Oka) or wild-type VZV. No other possible cases...
Barnes and Loutit first described (in mice) what is now known as graft versus host disease (GVHD) as a syndrome called secondary disease to differentiate it from primary disease of radiation sickness. Mice that were given allogeneic spleen cells after ir
Hood et al.24 reported rash with skin biopsy changes compatible with grade-2 GVHD in 8% of 115 recipients of auto- and genetically-identical twin transplants between 1977 and 1984. Typically the rash was self-limited. Some subjects received systemic corticosteroids. The cases were reported as ...
(skin rash), cutaneous blisters, crampy abdominal pain with or without diarrhea, persistent nausea and vomiting, hepatitis (with elevation of bilirubin and/or liver enzymes) (Jacobsohn D A and Vogelsang G B 2007). Clinical observations along with current diagnostic techniques are time-consuming and...
During the induction chemotherapy, the patient, transfused with whole blood and granulocytes, developed diarrhea and generalized macular rash. The skin biopsy showed some changes compatible with graft versushost disease (GVHD). Therefore, the related literature was reviewed, and the clinical features ...