Present study discloses that MnNG targets specifically wild-type-p53 expressing Hct116 and MCF-7 cells by significantly depleting both cytosolic, mitochondrial GSH, and modulating nuclear GSH through Glutathione reductase and Glutamate鈥揷ysteine ligase depletion that may in turn induce p53-mediated ...
The elevation in GSH was accompanied by elevated expression of glutamate鈥揷ysteine ligase modifier subunit, but no changes were observed in the expression of glutamate鈥揷ysteine ligase catalytic subunit and thioredoxin in de novo GSH synthesis. In the case of genes involved in the GSH ...