Acute GVHD usually involves the skin, gastrointestinal (GI) tract, and liver; this condition occurs in 70%, 74%, and 44% of cases, respectively. GVHD can also affect the lungs, kidneys, eyes, and hematopoietic system and may decrease responsiveness to active immunization. The most common skin...
Graft-vs-host diseaseGVHDGastrointestinal pathologyLiver pathologyObjectives: Graft-vs-host disease (GVHD) is a donor T-cell-mediated disorder affecting the recipient's skin, gastrointestinal tract, lungs, and liver. It complicates up to 70% of hematopoietic cell transplantation and is associated ...
2020-03-03上传 Graft-vs-host disease(移植物抗宿主病) 文档格式: .pdf 文档大小: 104.63K 文档页数: 4页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 论文--自然科学论文 文档标签: Graft-vs-hostdisease移植物抗宿主病
Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. About 35%–50% ...
It may, on occasion, be necessary to use differential lung ventilation to address the ventilatory requirements of the two lungs independently (Todd, 1990; Smiley et al., 1991). Fluid and blood product administration are limited as much as possible. As noted previously, inhaled NO may be ...
(p =0.045 and 0.009, respectively). There was no significant difference in hydroxyproline levels between the allo-rof05 and allo-rof10 groups.Immunohistochemistryresults forcollagen types I, II, and III in the lungs were the same as those for the hydroxyproline assay (seeSupplementary Figure ...
A computerized axial tomography (CAT) scan of the lungs revealed atypical infiltrates in both upper lobes, and antibiotic and antifungal therapy was initiated. Serological tests excluded recent viral or bacterial infection and bronchoalveolar lavage fluid was normal....
Fresh samples (N = 37) were harvested from the aGVHD and control group patients, including skin lesions, peripheral blood, and biopsy tissues of livers, intestines, ventricular walls, and lungs (TableS1). The RNA was extracted by Pre-NAT Full-Automatic System (PerkinElmer, Massachusetts, ...
Regulatory T cells (Tregs) have been implicated in the prevention of aGVHD in both mouse and man, while Th17 cells may modulate early inflammatory responses associated with aGVHD, especially those involving the skin and the lungs. Interestingly, these two lymphocyte subsets appear to be reciprocally...
The present invention provides a novel use and methods comprising antibodies, or antigen-binding fragments thereof, which bind to a CCR7 receptor for use as a novel therapeutic agent in prevention and/or treatment of graft versus host disease (GVHD), preferably in hematopoietic stem cell transplanta...