Yaromina A, Meyer S, Fabian C, Zaleska K, Sattler UG, Kunz-Schughart LA, Mueller-Klieser W, Zips D, Baumann M: Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo. Strahlenther Onkol 2012, 188 (5) : 431–437....
We found that the observed inhibition of glucose consumption, decreased phosphofructokinase activity, low lactate production, decreasing effect on ATP concentration, and the relationship of pyruvate kinase, lactate dehydrogenase and pyruvate concentrations similar to the results obtained by using human growth...
ATP-glycolysis-hexokinase deficiencyGlucose-P-isomerase deficiencyP-fructokinase deficiencyAldolase deficiencyTriose-P-isomerase deficiencyGlyceraldehyde-P-dehydrogenase deficiencyP-glycerate kinase deficiencyDiphosphoglycerate mutase deficiencyDiphosphoglycerate phosphatase deficiency...
In controls ATP was found to be 6.3, with low ADP and AMP, PKR 17.3 and glycogen 42.87 渭mol/g Fg, in the range of known normal values. In ischaemia, in agreement with findings in other organs, ATP falls to 12% after 3 h PKR after 1 h is 2.4% and after 2 h barely ...
In controls ATP was found to be 6.3, with low ADP and AMP, PKR 17.3 and glycogen 42.87 渭mol/g Fg, in the range of known normal values. In ischaemia, in agreement with findings in other organs, ATP falls to 12% after 3 h PKR after 1 h is 2.4% and after 2 h barely ...
Glycolysing cells are depleted from ATP in a few minutes.doi:10.1007/BF02157774H. TiedemannHeiligenberg-Institut (Abt. O. Mangold) und Chemisches Laboratorium der Universität Freiburg i. Br.H. J. RisseHeiligenberg-Institut (Abt. O. Mangold) und Chemisches Laboratorium der Universität Freiburg ...
3. Under control conditions 80% of the energy from glucose metabolism is converted to ATP. In the presence of phenylhydroxylamine, the formation of ATP is not decreased, but the transfer of energy to reduced pyridinnucleotides is increased in such a manner that only 20% appears in the form ...
Carcinophilin also initiates a rapid fall of the concentration of the ATP with an increase of ADP and AMP, as well as reduction of the ATP/ADP ratio. These changes may also be diminished by the addition of nicotinamide. The activity of the hexokinase in the homogenates of various human ...