The ADVANCE trial showed that SU-based regimen given with metformin reduced risk of microvascular complications. Also, the impact of intensive glycemic control on the micro- and macrovascular outcomes was similar irrespective of the baseline renal function (Ohkuma et al., 2020). Thus, the experts...
In such patients with metformin intolerance, some experts suggest initiation of therapy with 2 drugs from other antidiabetic drug classes with complementary mechanisms of action.Consider early initiation of combination therapy for the treatment of type 2 diabetes mellitus to extend the time to treatment...