broad genetic testing addresses the question of genetic causation more broadly (“agenetic etiology”) [47]. Broad testing has an increased probability of revealing incidental findings—which is the subject of ongoing debate about the consequences for patients and their families, interpretation of resul...
An individual's response to the first, or conditioning stimulus (C), is larger than to the second, or testing (T), stimulus. Although the whole EEG response to the second stimulus appears to be reduced, this starts with the P50 ERP. P50 suppression is normally expressed as the ratio of...
using published single-cell assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) data154. After Bonferroni correction across the 206 × 12 cell-type enrichments tested, we found significantly enriched heritability in four cell types, all non-neuronal...
Reference intervals (supine position; children) and standard preanalytical conditions (supine position for plasma determination, diet and medication interferences for urine testing) have to be carefully followed. Biochemical testing for PPGLs should be performed before imaging studies. Prior to the 24-h...
(Supplementary Fig.4, Supplementary Data5). Re-testing the effects of the four sentinel variants while adjusting for nearby blood composition-associated SNPs (<1 Mb) did not influence the results (Supplementary Data6, see 'Methods'). Second, we addressed unknown confounding by including latent...
We then used the Barker's system design method and a prototype to validate our proposed system via usability testing. This research has resulted in the development of the G3DMS that comprises: electronic data-capture forms for data entry; a customized query builder to display and modify patient...