An A/G-rich motif in the rat fibroblast growth factor-2 gene confers enhancer activity on a heterologous promoter in neonatal rat cardiac myocytes. Mol Cell Biochem 1998;188:169 - 76.Detillieux K. A. , Meyers A. F. , Meij J. T. and Cattini P. A. ( 1998 ) An A/G-rich motif...
Cytotoxic G-rich oligodeoxynucleotides: putative protein targets and required sequence motif 来自 掌桥科研 喜欢 0 阅读量: 29 作者:G Amber,K Andrew,GM Margaret,P Toby,T Carly,R Laurent 摘要: It has recently been shown that certain oligodeoxynucleotides (ODNs) designed as catalytic DNA molecules ...
Small change in a G-rich sequence, a dramatic change in topology: new dimeric G-quadruplex folding motif with unique loop orientations - Crnugelj, Sket, et al. - 2003Crnugelj M,Sket P,Plavec J.Small Change in a G-rich Sequence. a Dramatic Change in Topology:New Dimeric G-Quadruplex ...
Vibrio choleraetoxin andEscherichia coliheat-labile enterotoxin were targeted for aptamer development.Magnetic-bead SELEX was performed and combined with Next Generation Sequencing for sequence analysis.Enrichment in common enterotoxin-binding sequences containing a dominant G-rich motif was observed.The foldi...
We show that instability does not correlate with enrichment of the WRC sequence motif that is the consensus for deamination by AID. Instability does correlate with G-richness, evident as multiple runs of the base guanine on the nontemplate DNA strand. Extending previous analysis of c-MYC, we ...
Polo kinasekinase specificityshort linear motifSLiMintrinsically disordered regionsThe hydrophobic patch ( ), a docking pocket on cyclins of CDKs (cyclin-dependent kinases), has been thought to accommodate a single short linear motif (SLiM), the "RxL or Cy" docking motif. Here we show that can...
Such sequences are found in both RepE and RCMLA, thus it remains unclear whether the higher affinity for RepE is due to the greater exposure of a sequence motif or to a specific folding pattern. Our data indicate that RepE could directly contact the G/F-rich region and Zn-binding domain...
To answer the fundamental biological question of what the role of noncritical disulfide bridges is, we investigated function and folding of disulfide-depleted analogs of -conotoxin GVIA (GVIA) that belongs to an inhibitory cystine knot motif family and blocks N-type calcium channels. Removal of ...
Similar to web-logo motif analyses of CAGE peaks from different mRNA regions (Fig. 2A, Additional file 1: Fig. S2F), the nucleotide enrichment plot of GGG sequences showed the highest enrichment overlapping 3′UTR CAGE peaks (Fig. 2C, Additional file 1: Fig. S2F). This raises the ...
The color motif is contrasted by carbon fiber bits, predominantly on the dashboard trims and the steering wheel. To emphasize luxury, the G63 gets a starlight headliner - something you would commonly see in Rolls-Royce cars. There are also Keyvany badges in the interior, including on the ...