ON THE FUNCTIONS AND USES OF THE THYMUS GLAND.ON THE FUNCTIONS AND USES OF THE THYMUS GLAND.. By - H.G. Wrightdoi:10.1016/S0140-6736(02)88437-9WrightH.G.Elsevier Ltd.Lancet
Its main role in the immune system is to produce specialized T cells that target foreign pathogens or cancer cells. What are some disorders of the thymus gland? Thymus cancers are rare but include thymoma and thymic carcinoma, the latter of which is harder to treat. DiGeorge syndrome is a ...
Thyrotropin-releasing hormone (TRH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. This was employed in the TRH stimulation test, which is currently little used. The role of TRH as a cancer biomarker is minor,...
They are important for normal embryonic development and are involved in diseases such as cancer. Both histones and non-histone proteins are targets for the histone demethylases. Examples of non-histone substrates include p53, DNA methyltransferase 1 (DNMT1) and E2F1. Histone demethylase activity is...
Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative...
Finally, the expression of cyclin E1 and E2 is not always linked in cancer, and this discordance confirms that there are likely to be underlying functional and regulatory differences between the two proteins. Known functions of the E-cyclins The E-type cyclins activate the kinase Cdk2 that ...
cancer. Data from epidemiologic, animal and clinical studies collectively support preventive functions of THs in liver-related diseases, highlighting the therapeutic potential of TH analogs. Elucidation of the molecular mechanisms and downstream targets of TH should thus facilitate the development of ...
With the technical advances of the past few decades, there has been increasing emphasis in neurophysiology and neuropharmacology on studies at the cellular and subcellular levels, as illustrated by most of the chapters in the present volume. The magnitudes and sequences of the electrical signs associ...
the local environment. In this Review, we consider evolving insights into the tissue distribution of eosinophils and their functional immunobiology, which enable eosinophils to secrete in a selective manner cytokines and other mediators that have diverse, 'non-effector' functions in health and disease....
These studies provide insights into how they acquire these properties, through both developmental programming in the thymus and functional polarization in the periphery. Innate features of γδ T cells underlie their non-redundant role in several physiopathological contexts and are therefore being ...