Examples of the other active includes metformin, telmisartan and glitazone. The dosage of linagliptin is 2.5 mg or 5 mg and the dosage is for oral administration.DUGI KLAUSHIMMELSBACH FRANKMARK MICHAEL
This review will also emphasize the recent strategies and rationale utilized by researchers for the development of DPP-4 inhibitors. This review also reveals about the various other approaches like molecular modelling, ligand based drug designing, high throughput screening etc. are used by the various...
As further DPP-4 inhibitors the following compounds can be mentioned: Sitagliptin (MK-0431) having the structural formula A below is (3R)-3-amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one, also name...
Examples of such known prophylactic or therapeutic agents for diabetes include DPP-4 inhibitors such as sitagliptin, vildagliptin, alogliptin, linagliptin, teneligliptin, anagliptin and the like, anti-diabetes drugs such as insulin, tolbutamide, glyclopyramide, glibenclamide, metformin, epalrestat, ...
Subsequent steps are similar to standard staining with the supplementation of phosphatase inhibitors. Appropriate primary antibodies were added to the samples and incubated at 4°C overnight. The following primary antibodies were used: mouse monoclonal antibody (mAb) anti-Dl (C594.9B, 1:50), mouse...
The present invention relates to process for preparation of novel compounds which are acting as inhibitors of dipeptidyl peptidase-IV enzyme and is depicted by the structural formul
DPP-IV inhibitors have been suggested as drug candidates for the treatment of impaired glucose tolerance and type 2 diabetes mellitus (e.g. Villhauer, WO98/19998). Other related state of the art can be found in WO 99/38501, DE 19616486, DE 19834591, WO 01/40180, WO 01/55105, U.S....
In 2006 first DPP-4 inhibitor was familiarized, signifying that they have the potential needed to treat diabetes and imitates lesser side effects, are highly potent, long-acting, and with a bioavailability of >90% & hence oral anti-hyperglycemic inhibitors got the focus of researchers and ...
The industrial processing of Argentine shortfin squid to obtain rings generates a significant amount of protein-rich waste, including the skin, which is rich in collagen and attached myofibrillar proteins. This waste is generally discarded. In this study