The 2-year survival rate was also lower in the diffuse midline glioma with 22.6% vs 39.1% in the control. This poorer outcome could be related to the slightly lower median performance status or the lack of complete resection in diffuse midline glioma patients. Additional analysis is being ...
wherein the stem-like and tumor-initiating characteristics are driven by a population of less-differentiated OPC-like glioma cells while the more differentiated AC-like glioma cells represent a minority12. We demonstrated that this tumor heterogeneity can be modeled in vitro and is substantially...
Diffuse midline glioma, H3 K27-altered is defined as a tumor found in the thalamus, brainstem, spinal cord, and occasionally in the pineal gland, the hypothalamus or the cerebellum [57]. However, in clinical practice, H3 K27M-mutant diffuse gliomas could exist at the anatomically non-midline...
Shilatifard A, Saratsis AM. Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma. Acta neuropathologica communications. 2017 Apr 17:5(1):28. doi: 10.1186/s40478-017-0436-6. Epub 2017 Apr 17[PubMed PMID: 28416018] ...
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location Ilon Liu, Li Jiang, Erik R. Samuelsson, Sergio Marco Salas, Alexander Beck, Olivia A. Hack, Daeun Jeong, McKenzie L. Shaw, Bernhard Englinger, Jenna ...
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma. J Neuroinflammation. 2022;19(1):276. Article CAS PubMed PubMed Central Google Scholar Werbrouck C, Evangelista CCS, Lobón-Iglesias MJ, Barret E, Le Teuff G, Merlevede...
diffuse midline gliomaH3 K27M mutationoverall survivalspinal cordtumor locationWe investigated the risk factors for diffuse midline gliomas of the spinal cord (DMGSCs). Seventy patients with spinal cord gliomas in two hospitals were analyzed retrospectively. Sixty-nine patients that underwent surgery ...
midline gliomaPD‐L1pediatricT cellDiffuse midline gliomas (DMGs) are rare and devastating tumors with limited therapeutic options. Programmed death‐ligand 1 (PD‐L1) expression represents a potential predictive biomarker for immunotherapy. One hundred and twenty‐six DMGs (89 adult and 37 pediatric...
The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of its phosphata
The most lethal subtype of diffuse intrinsic pontine glioma (DIPG) is H3K27M. Although ACVR1 mutations have been implicated in the pathogenesis of this currently incurable disease, the impacts of bone morphogenetic protein (BMP) signaling on more than 60