We focused on hsa_circ_0003506, which was spliced from CYFIP2 gene located at chr5:156786012-156788606 and finally formed a sense-overlapping circular transcript of 366 nt, and thus we named it circCYFIP2. CircCYFIP2 was found to be significantly upregulated in GC tissues and cell lines....
Mutations in the cytoplasmic FMRP-interacting protein 2 (CYFIP2) gene were recently described as possible causes of WS. CYFIP2 has a role in actin polymerization through WAVE regulatory complex (WRC), especially on dendritic spines and synaptosomes. To study the molecular mechanism of mutation in...