Treatment duration was 24 weeks. The mean cyclosporine dose at the last visit was 2.91 mg/kg/day (range: 0.72 to 5.17) for cyclosporine oral solution, USP MODIFIED and 3.27 mg/kg/day (range: 0.73 to 5.68) for cyclosporine. See graph below....
Adjunct therapy with adrenal corticosteroids is recommended initially. Different tapering dosage schedules of prednisone appear to achieve similar results. A representative dosage schedule based on the patient's weight started with 2.0 mg/kg/day for the first 4 days tapered to 1.0 mg/kg/day by 1 ...
A randomized, unmasked, multicenter study was conducted to evaluate the rate of pruritus reduction and improvement in clinical scoring by cyclosporine A (5 mg/kg orally, once daily for 28 days) either alone (n = 25 dogs) or with concurren
Four groups were studied for GVHD prevention: six dogs in group 1 received MMF 10 mg/kg twice daily subcutaneously (SC) on days 0 to 27. They died between 8 to 28 days from infection or GVHD; survival was better than that of 72 controls given no immunosuppression (P = .04), but ...
Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after marrow transplantation. Blood., 89 (1997), pp. 3048-3054 CrossrefView in ScopusGoogle Scholar 14 EW Petersdorf, TA Gooley, C Anasetti, et al...
Dogs were randomly assigned to receive either MNA 715 and cyclosporine (n = 8) or cyclosporine alone (n = 6). Dogs were killed at 100 days after transplantation or when plasma creatinine exceeded 7 mg/dL. Results— In the cyclosporine and MNA 715 group: 4 dogs survived to 100 days with...
which were determined in the same reproducible way, at the same dosage, using the same dogs. [0085] Examples AUC (0-12 h) ng/ml 1 26.555 ± 7.195 2 24.832 ± 10.206 3 17.828 ± 8.193 4 33.109 ± 11.504 cyclosporin capsules (comparison) (Sandimmun ® Optoral) preparation for compari...
PURPOSE: Cryopreserved arterial allografts may be used for arterial reconstructive procedures. In this experimental study cryopreserved arteries were used as autografts and as allografts with or without immunosuppression with cyclosporine A. METHODS: In group A (three dogs, six bilateral grafts) ...
In dogs, cyclosporine has been used in the treatment of CE and protein-losing enteropathy [40,41,42]. Steiner and Huber [21] published a case report on a dog with atopy, DM and a supranormal serum canine pancreas-specific lipase (Spec cPL) concentration. The dog was treated with cyclospo...