The dialyzability of cyclophosphamide was investigated in four patients on long-term hemodialysis. Dialysis clearance calculated by arterial-venous difference and actual drug recovery in dialysate averaged 104 mL/min, which is in the range of the metabolic clearance of 95 mL/min for the drug. A ...
Possible adverse effects seen with cyclophosphamide include infertility, amenorrhea, alopecia, cardiotoxicity, infections, and secondary malignancies. Hemorrhagic cystitis is more commonly associated with long-term oral cyclophosphamide treatment; however, patients receiving cyclophosphamide should be adequately hydra...
Male children, including prepubertal males receiving high-dose cyclophosphamide therapy, are at high risk for long-term, irreversible gonadal damage (e.g., infertility, subclinical Leydig cell insufficiency).Inform patients of possible fertility impairment and counsel on fertility options prior to therapy...
THE LONG-TERM OUTCOME OF CYCLOPHOSPHAMIDE ORAL VERSUS INTRAVENOUS IN CHINESES CHILDREN WITH STEROID DEPENDENT NEPHROTIC SYNDROMEObjectives: To investigate the effects of oral or intravenous cyclophosphamide with steroid dependent nephrotic syndrome(SDNS) children. Method: Sixty-nine SDNS children(39 girls ...
A cytoreductive regimen in preparation for bone marrow transplantation that consists of cyclophosphamide in combination with whole-body irradiation, busulfan, or other agents has been identified as a major risk factor.VOD has also been reported to develop gradually in patients receiving long-term low-...
The appearance of hemorrhagic cystitis and bladder carcinoma has been well documented in patients receiving long-term oral CY.24 The role of BK virus, present in the majority of adults in latent form in the urogenital tract, and its reactivation following CY therapy are currently been explored. ...
Beside acute side effects like bone-marrow toxicity, infections, haemorrhagic cystitis, gastrointestinal side effects and hair loss, the main concern is the long-term effect of the drug which may occur years after treatment when patients with end-stage renal disease have received a transplant. ...
Long-term effects of cyclophosphamide therapy in steroid-dependent or frequently relapsing idiopathic nephrotic syndrome. Nephrol Dial Transpl. 2011;26(1):178–84. https://doi.org/10.1093/ndt/gfq405. Epub 2010 Jul 7. PMID: 20610527. Article CAS Google Scholar Latta K, von Schnakenburg C, ...
Training programs should contain information on the therapeutic and adverse effects of these drugs and the potential, long term health risk to personnel handling these drugs. Each individual's knowledge and technique should be evaluated before administration of these drugs. This should be done by ...
Training programs should contain information on the therapeutic and adverse effects of these drugs and the potential, long term health risk to personnel handling these drugs. Each individual's knowledge and technique should be evaluated before administration of these drugs. This should be done by ...