1). Cyclophosphamide exhibit the bimodal mechanism of antitumor action with cardiotoxic effect and immunomodulatory effects [14]. The difference in pharmacological effect depends on the metabolism of the drug, the dose administered, dosing schedule and timing of the dosing. [15]. CP or its ...
The present paper presents a DFT investigation of the different metabolic phases and an insight into the mechanism by which CP exerts its cytotoxic action. A detailed computational analysis of the energy profiles describing all the involved transformations and the mechanism of DNA alkylation is given ...
Mechanism of action Cyclophosphamide can be given orally, intramuscularly, or intravenously. The plasma half-life of intact cyclophosphamide is 6.5 hours.Only 10 to 15% of the circulating parent drug is protein bound, whereas 50% of the alkylating metabolites are bound to plasma proteins. Since ...
facial swelling, headache,nasalcongestion, scalp burning), cyclophosphamide should be injected or infused very slowly. Duration of the infusion also should be appropriate for the volume and type of carrier fluid to be infused.
Cyclophosphamide can cause fetal harm when administered to a pregnant woman based on its mechanism of action and published reports of effects in pregnant patients or animals. Exposure to cyclophosphamide during pregnancy may cause fetal malformations, miscarriage, fetal growth retardation, and toxic effect...
The mechanism of action for this antibody is not clearly known, but it can induce apoptosis of these developing B cells after binding and induce B cell depletion. Of note, B cell stem cells and plasma cells do not express CD20 and thus are not affected by rituximab. In the Rituximab in ...
The mechanism of action of Cyclophosphamide monohydrate involves the formation of active metabolites that crosslink DNA strands, leading to DNA damage and ultimately cell death. Storage Conditions: Store in a cool and dry place. View all 3.3 General Description Fine white crystalline powder with...
Influences of FVP_1 on the curative and negative effects of CTX; 金针菇多糖对环磷酰胺的增效减毒作用 3. Antagonistic Effect of Lizhong Decoction Against Genetic Toxicity of CTX; 理中汤对环磷酰胺遗传毒性的拮抗作用 更多例句>> 5) cytoxan 环磷酰胺 1. Study of Mechanism of Combined Treatment of...
(1984); of clinical toxicology: L. H. Fraiseret al.,Drugs42,781-795 (1991); of mechanism of action and clinical use: O. M. Colvin,Curr. Pharmaceut. Design5,555-560 (1999); of analytical methods: M. Malet-Martinoet al.,ibid.561-586; and metabolism: F. Baumann, R. Preiss,J....
It was reported earlier that several antitumor compounds act through the antimutagenic mechanism [53], [54], [55]. Hence, searching for the antimutagenic compounds represents a rapidly expanding field of cancer research [56], [57], [7], [58]. Plants having anti-mutagenic potential can also...