提供的CTSK人源重组蛋白(P01)产品为带有GST标签的人源CTSK全长序列重组蛋白,其对应的GeneID号为1513。 产品描述 与其它公司提供的重组蛋白不同,该CTSK人源全长重组蛋白(P01)产品为采用CFS的无细胞麦胚蛋白合成系统表达出来的重组蛋白,可表达出对细胞有毒性、易被蛋白酶降解的蛋白;并获得具有良好的可溶性,并有翻...
Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] [中文简述(自动翻译):] 由该基因编码的蛋白质是参与骨重建和再吸收溶酶体半胱氨酸蛋白酶。这种蛋白质,它是肽酶的C1蛋白家族的一个...
致密性成骨不全症组织蛋白酶K基因复合杂合突变The purpose of this study was to analyze the clinical characteristics of a patient with pycnodysostosis caused by cathepsin K ( CTSK ) gene mutation and his family members in order to improve the understanding of this rare diseases. A pediatric ...
Next generation sequencing (NGS) and Sanger sequencing confirmed that the proband carried carryingcompound heterozygous mutations of cathepsin K(CTSK) gene, including a missense mutation c.440C>T in exon 5(p.Ala147Val) and a deletion mutation c.778delA in exon 6 (p.Ser260AlafsX15) which ...
Pycnodysostosis is a rare autosomal recessive skeletal dysplasia characterized by short stature, osteosclerosis, acro-osteolysis, frequent fractures and skull deformities. Mutations in the gene encoding cathepsin K (CTSK), a lysosomal cysteine protease,
The CTSK gene was sequenced by the Sanger method in the patients and their parents. In addition to 18 families from Ceará, this study also included 15 families from other Brazilian regions. We also investigated the origin of each family from the birthplace of the parents and/or grandparents....
A Recurrent Mutation in CTSK Gene is Responsible for Autosomal Recessive Pycnodysostosis in Consanguineous Pakistani Families Aspirin dose-dependently reduced the formation of TRAP positive cells from RAW 264.7 macrophage cell line and the mRNA expression of osteoclast markers, namely, TRAP, CTSK, MMP...
CDS-R02118-1 pDonR223-CTSK GateWay 2ug/0.5ml ￥0 现货 CDS-R02118-2 pMD18-T-CTSK TA克隆 2ug/0.5ml ￥0 1-2周CTSK 重组病毒 货号产品名称Method规格价格货期 CDS-R02118-11 rAd-CTSK 重组腺病毒 10^10cfu/支 ￥3000 3-5周 CDS-R02118-12 rAAV-CTSK 重组腺相关病毒 10^11cfu/支 ￥30...
is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteoscle...
重组蛋白主要有四大表达系统:原核细胞(主要是)、酵母细胞、昆虫细胞、以及哺乳动物细胞表达系统。此外,我们也可以利用植物、动物器官(如乳腺等)生产重组蛋白。 重组蛋白(recombinant protein)是指应用重组 DNA 或重组 RNA 技术而获得的蛋白质。重组蛋白工程先应用基因克隆或化学合成技术获得目的基因(gene of interest,GOI...