20 Our results seem to be in line with these findings, because we found a significant positive correlation between Ang-2 and CSF-1 serum levels in patients with NSCLC , meaning that when circulating levels of CSF-1 are high, so are the Ang-2 levels, suggesting a combined involvement of ...
Preferably administration of the two active agents is "essentially simultaneous", meaning the GM-CSF and tumor antigen are administered to the same peripheral location at the same treatment time to induce their synergistic effect. Most preferaly, tumor antigen is administered to the same subcutaneous...
To further strengthen the meaning and value of this myelin biomarker, it will be extremely interesting to translate these evidences to central demyelination, namely multiple sclerosis. This would allow us to candidate SM assay as a novel CSF index to be routinely used in neurological clinical ...
The "heterogeneous" group showed peculiar activation of genes coding for ribosomal components, meaning that in these patients a different molecular effect of nusinersen is observable, even if this specific molecular response was not referable to a clinical pattern.#This study provides preliminary ...
2seventy bio Cautionary Note Regarding Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, the research, development and commercialization of Abecma® (idecabtagene ...
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The kinetics of amyloid beta turnover within human brain is still poorly understood. We previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not known if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) fluid exchange, CSF turnover, blood-brain ba...
(c,d). These analyses were multivariable, meaning that outcome predictors are independently significant even when adjusting for previously known prognostic covariates following a severe TBI. Validation of results were conducted in an independent TBI cohort without CSF samples. Following TBI, many of ...
First-exposure adaptive resistance to aminoglycoside antibiotics in vivo with meaning for optimal clinical use. Antimicrob Agents Chemother. 1991;35:117–23. Article PubMed CAS Google Scholar Sörberg M, Hanberger H, Nilsson M, et al. Pharmacodynamic effects of antibiotics and acid pump ...