CpG Shores指的是位于CpG island上下游2kb 以内的区域;CpG Shelves指的是位于CpG shores上下游2kb以内的区域;open sea指的是CpG islands,CpG shores,CpG shelves之外的其他区域。 可以看到,位于open sea的探针是最多的。
而那些可被甲基化的CpG 二核苷酸并非随机的分布于基因组序列中,相反,在基因组的某些区域中,通常是基因的启动子区域,5’端非翻译区和第一个外显子区,CpG序列密度非常高,超过均值5倍以上,成为鸟嘌呤和胞嘧啶的富集区,称之为CpG岛(CpG Islands, CGIs) 最近,为了排除那些Alu重复序列,提出了更严格的标准:长度至少...
CpG islands methylation induced by beta-carotene and arachidonic acid in human endothelial cells and its progenitors .DNA methylation is a mechanism regulating gene expression. Beta-carotene (BC), potent pro-vitamin A/retinoic acid source in human, was shown to have pro-chemotactic activity and ...
CpG Shores指的是位于CpG island上下游2kb 以内的区域;CpG Shelves指的是位于CpG shores上下游2kb以内的区域;open sea指的是CpG islands,CpG shores,CpG shelves之外的其他区域。 可以看到,位于open sea的探针是最多的。
1.Research on Gene Chip for Methylation Detection of 5'CpG Islands;5'CpG岛甲基化检测基因芯片的研究 2.The Status of 5 CpG Island Methylation of p16 Gene Promoter in Gastric Carcinoma;胃癌p16基因启动子5’CpG岛甲基化状态 3.Hypermethylation of CpG island at p16 gene promoter in gastric carcinoma...
网络岛甲基化 网络释义 1. 岛甲基化 CpG岛甲基子表型,... ... ) CpG island methylator phenotype 岛甲基子表型 )CpG island methylation岛甲基化) CpG Islands 岛 ... www.dictall.com|基于2个网页 例句 释义: 全部,岛甲基化
在甲基化芯片中,对于CpG位点所在的区域,会有对应的注释信息,比如CpG islands。CpG island是基因组上一段CpG位点密度较高的区域,这个概念是非常常见的 ,出了CpG island 之外,还会有CpG shores, CpG shelves, open sea等情况,这些区域又是如何定义的呢? 有一篇文章详细评估了 450K芯片所检测的CpG位点在人类基因组...
2. Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer, Nat Rev Genet 3(6):4z15−428. 3. Shi H, Wang MX, Caldwell CW (2007) CpG islands: their potential as biomarkers for cancer, Expert Rev Mol Diagn 7(5):519−531....
CpG islands are short stretches of CpG rich regions that are frequently associated with the promoter region of genes. Aberrant methylation of CpG islands is one mechanism of inactivating tumor suppressor genes (TSGs) in neoplasia, and there is growing evidence that altered cytosine methylabtion play...
3) Promoter CpG islands 启动子区域CpG岛4) CpG island methylator phenotype CpG岛甲基子表型 1. Clinicopathologic features of sporadic colorectal cancers with CpG island methylator phenotype; CpG岛甲基子表型阳性的散发性大肠癌的临床病理特征5) CIMP CpG岛甲基化表型(CIMP)...