hypothesized to explain the clustering of unmethylated CpG motifs inCpG islandsnear the promoters of ∼50% of mammalian genes. The MBD domain of MBD4 binds with highest affinity to methylated CG/TG mismatched sequences, and the protein also contains aglycosylaseactivity in its carboxyl term...
Using our measure of inter-individual differences, we observed that 61.2% of the probes classified as being variable were in CpG islands versus 75.4% of the probes classified as being non-variable. We therefore replicate the findings of Bock et al. Implications of this finding are that, for ...
Parental DNA methylation and histone modifications undergo distinct global reprogramming in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its effects on embryogenesis are largely unknown. Here we comprehensively analys