In this study, we found that three grading scales, the NIH eye score, the Japanese dry eye score and the DEWS 2007 score, showed statistically good agreement in the diagnostic rate and the severity of ocular GVHD. The clinical manifestations and pathology of ocular GVHD have been previously st...
Whether the new NIH cGVHD global severity grading correlates with patient reported QOL is not known. In a prospectively assembled multi-center observational cohort study of adult HCT recipients with cGVHD, we examined the relationship between cGVHD severity according to NIH criteria and patient-reported...
Validation of NIH consensus criteria for diagnosis and severity-grading of chronic graft-versus-host disease Int J Hematol, 97 (2013), pp. 263-271 CrossrefView in ScopusGoogle Scholar 10 M. Arora, S. Nagaraj, J. Witte, et al. New classification of chronic GVHD: added clarity from the ...
The best tools that we have for risk assessment and staging right now are based on the NIH [National Institutes of Health] consortium that meets every several years. They’ve created a grading system for every organ that can be potentially involved. This has allowed us to conduct clinical ...
Diagnosis and grading of GVHD The diagnosis, organ scoring and global assessment of cGVHD were based on the National Institutes of Health (NIH) consensus criteria for cGVHD.25The onset forms of cGVHD were determined according to the published classifications.26 ...
A retrospective chart review was performed on seven patients treated with topical ocular corticosteroid therapy for progressive cicatricial conjunctivitis associated with chronic graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. A clinical grading criteria for conjunctival GVHD ...
Platelet count at diagnosis remains the most valid prognostic factor for survival of patients with cGvHD even in the era of NIH grading. High IgG level at diagnosis of cGVHD represents a potential negative prognostic parameter that deserves further investigation....
Ocular graft-versus-disease (GVHD) is a common complication after hematopoietic stem cell transplantation (HSCT). Here we compared the diagnostic rates of ocular GVHD, including its severity, prognosis and the agreement, obtained usin...
Thus, ancillary therapy and supportive care become central components in the long-term management of chronic GVHD after allogeneic hematopoietic cell transplantation (HCT). As in the 2005 National Institutes of Health (NIH) consensus framework, “ancillary therapy and supportive care” embraces the ...
Prior acute GVHD, n (%)† Yes 135 (76) 24 (73) .70 No 43 (34) 9 (37) Time post-HCT to cGVHD diagnosis, d Median 210 NA NA Range 38-1757 NA Time post-HCT to sample acquisition, d Median 391 369 .84 Range 192-1852 161-3641 NIH global severity, n (%)† Mild 13...