Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity. The MadMyc-induced G1 arrest is rescued by ectopic expression of cyclin E/CDK2 and cyclin D1/ CDK4, but not by Cdc25A, a known cell cycle ... K Berns,EM Hijm...
cdc25 is a family of phosphatases that activate the cyclin-dependent kinases at different points of the cell cycle. cdc25A and -B, but not -C, have been shown to have oncogenic potential. Three different splicing variants of the cdc25B gene, cdc25B1, -B2 and -B3, ha...
产品介绍:Cyclin dependent kinases are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin dependent kinases is also regulated by the phosphorylation status, which is controlled by the antagonistic action of Wee1 kinase and C...
该研究发现细胞周期调节因子Cdc25A可通过去磷酸化糖酵解关键酶PKM2参与肿瘤细胞代谢调控。 Cdc25A (M-phase inducer phosphatase 1)在多种人类肿瘤细胞中高表达。以往研究报道其主要通过去磷酸化CDKs (Cyclin-dependent kinases)发挥促进细胞周期进展的作用。然而,Cdc25A是否存在其他底物,及该底物的去磷酸化参与何种细...
CDC25是一种双特异性磷酸酶,可以通过催化细胞周期依赖性蛋白激酶(cyclin-dependent protein kinases,CDK)分子中的抑制性磷酸化位点去磷酸化从而激活CDK,并调控应对DNA损伤,推动细胞周期运行。人类CDC25主要包括CDC25A、CDC25B、CDC25C 3种亚型,其中CDC25A是控制G1/S期和G2/M期检查点的“开关”蛋白,在维持DNA复制...
Oncogene-induced replication stress, for instance as a result of Cyclin E1 overexpression, causes genomic instability and has been linked to tumorigenesis. To survive high levels of replication stress, tumors depend on pathways to deal with these DNA lesions, which represent a therapeutically actionable...
产品描述 概述 CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, ...
Objective: To explore the protein-protein interactions between the cell division cyclin 25B(CDC25B) and Cyclin A and cyclin-dependent kinase 2(CDK2). Methods: The docking analysis of CDC25B and CDK2/Cyclin A was performed using the protein-protein docking algorithm ZDOCK embed in Discovery Stu...
The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cyclin A in comple
1mg/ml Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Background: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by remo...