The National Kidney Foundation (NKF) guidelines identify 5 stages of CKD for monitoring and treatment based on creatinine clearance (CrCl) or glomerular filtration (GFR) estimates; today one may choose between C-G, MDRD and CKD-EPI formula to estimate CrCl or GFR. We derived and compared GFR...
iii. Adequate renal function, creatinine clearance, as measured by the Cockcroft and Gault formula of > 50mls/minute. iv. Adequate cardiac function: left ventricular ejection fraction ≥ 50% (INTEGRATE IIa only). 7. Study treatment to start within 7 days of randomisation Main exclusio...