CpG islands in MyD88 and ASC/PYCARD/TMS1 promoter regions are differentially methylated in head and neck squamous cell carcinoma and primary lung squamous cell carcinomaHNSCCSecond primary tumorLungDiagnostic biomarkerMethylationCpGBackground Patients with head and neck squamous cell carcinoma (HNSCC) can...
Although methylation of CpG islands within gene promoters is generally known to be associated with downregulation of expression, it remains unclear which methylated loci are most important in driving differential expression. Although the TCGA Pan-Cancer project has identified for each gene the single CpG...
CpG sites more frequently methylated in females were more often located near transcriptional start sites (TSS1500) and within CpG islands, S_shores and S_shelves. Conversely, CpG sites more frequently methylated in males were enriched within gene bodies and 3′U TR, and were associated with...
The study of transgene methylation has shown thatmethylation patterns can be inherited in a parent-of-origin-specific manner3–7, suggesting that DNA methylation may play a role in genomic imprinting. Are imprinted genes near differentially methylated regions? Imprinted genes are typically associated wi...
In mammals, the majority (70-80%) of CG dinucleotides are methylated, with the exception of stretches of sequence rich in CG dinucleotides called CpG islands (CGIs) [13]. CGIs are generally not methylated, but can be targeted for methylation under particular conditions [14]. When methylation...
7 Aberrant methylation of CpG islands in promoters is associated with transcriptional inactivation of genes involved in all aspects of tumor development. Genes involved in DNA damage response, cell cycle control, apoptosis signaling, drug metabolism, detoxification, angiogenesis, DNA repair, intercellular ...
Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals. We show that CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell line
KDM2B links the polycomb repressive complex 1 (PRC1) to recognition of CpG islands eLife, 1 (2012), p. e00205 Google Scholar Garcia-Cuellar et al., 2016 M.P. Garcia-Cuellar, C. Büttner, C. Bartenhagen, M. Dugas, R.K. Slany Leukemogenic MLL-ENL fusions induce alternative chromatin...
Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrocopy derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrocopy and is not imprinted. We have investigated...
CpG sites more frequently methylated in females were more often located near transcriptional start sites (TSS1500) and within CpG islands, S_shores and S_shelves. Conversely, CpG sites more frequently methylated in males were enriched within gene bodies and 3′UTR, and were associated with open ...