Excellent Aldehyde and Ketone Selectivity in Chromium(II)-Mediated Reformatsky Reactionsvs vs.doi:10.1055/s-1997-3239Wessjohann, LudgerWild, HarrySynlett
In addition to cyclic ketones, high diastereoselectivity is also observed in nucleophilic additions to acyclic o-substituted benzaldehyde or aryl ketone chromium complexes. Additions of Grignard or organolithium reagents to (o-substituted benzaldehyde)Cr(CO)3 afford predominantly one diastereomer 39 (Schem...
-one. for example, retinal is an aldehyde required for vision. the first part of the name indicates that this compound is present in the retina and the suffix tells us that it is an aldehyde. another example of a common name is alpha ionone, a fragrant ketone responsible for the scent ...
Fig. 3: Synthesis of the C14–C26 methyl ketone 33. Two separate asymmetric α-chlorination reactions are employed in the synthesis of the chloroketone33required for the key Corey–Chaykovsky coupling. LDA lithium diisopropyl amide, dpm dipivaloylmethanato, DBU 1,8-diazabicyclo[5.4.0]undec-...
Wessjohann L,Wild H.Excellent aldehyde and ketone selectivity in chromium (Ⅱ)- mediated Reformatsky reactions.. Synlett . 1997Wessjohann L,Wild H.Excellent aldehyde and ketone selectivity in chromium (Ⅱ)- mediated Reformatsky reactions..Synlett. 1997...
Various types of α-bromo aldehyde and ketone derivatives of nitroxyl radicals can be prepared in a selective bromination reaction with pyrrolidone hydrotribromide in the presence of a double bond. The saturated α-bromo aldehydes are dehydrobrominated with 1,8-diazabicyclo [5,4,0]undec-7-ene....
vs.ketoneselectivityPetersonmethylenationTris(trimethylsilylmethyl)alane (TTMA) is a rapid, efficient, and highly aldehyde-selective trimethylsilylmethylating reagent. A solid lithium halide complex of the reagent, TTMA · 3LiBr (TTMAs), is particularly effective in this transformation to the ...