Ghrelin receptor (GHS-R1A) antagonism sup- presses both operant alcohol self-administration and high alcohol consumption in rats. Addict. Biol. 17 (1), 86--94.Landgren S, Simms JA, Hyytia P, Engel JA, Bartlett SE, et al. (2011) Ghrelin receptor (GHS–R1A) antagonism suppresses both ...
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied as a crucial modulator. The major proportion of circulating ghrelin is however the non-octanoylated form o
A literature-based, functional analysis of the interactions of the products of these candidate genes defined pathways linked to presynaptic GABA release, activation of dopamine neurons, and postsynaptic GABA receptor trafficking, in brain regions including the hypothalamus, ventral tegmentum and amygdala....
Sensitivity to threshold doses of D-[LYS3]-GHRP-6 suggests that an augmented ghrelin system may contribute to increased alcohol reward in RYGB. Further research is warranted to confirm applicability of these findings to humans and to explore ghrelin-receptor targets for treatment of alcohol-related...
Experimental studies have also demonstrated that ghrelin receptor antagonist reduces alcohol intake, the motivation to consume alcohol and human studies report that ghrelin enhances craving for alcohol in alcohol-dependent heavy drinkers (for review see e.g. (Engel and Jerlhag, 2014b, Leggio et al....
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive and more susceptible to developing cirrhosis and hepatocellular carcinoma. Currentl
期刊名称:《Alcohol and alcoholism: international journal of the Medical Council on Alcoholism》 | 2014年第4期 4.One hundred years of alcoholism: the Twentieth Century. 机译:酗酒一百年:二十世纪。 作者:Mann K;Hermann D;Heinz A 期刊名称:《Alcohol and alcoholism: international journal of the ...
We iterate the therapeutic potential of ghrelin receptor antagonists, oxytocin, neurokinin 1 receptor antagonists, and glucagon-like peptide-1 receptor agonists. In the context of neuroinflammatory/neuroimmune modulators, we draw attention to P2X4 receptor positive allosteric modulators and phosphodiesterase ...
Common structural basis for constitutive activity of the ghrelin receptor family. J Biol Chem. 2004;279:53806–17. Article CAS Google Scholar Holst B, Egerod KL, Schild E, Vickers SP, Cheetham S, Gerlach LO, et al. GPR39 signaling is stimulated by zinc ions but not by obestatin. ...
Nicotinic acetylcholine receptorPersonalitySingle nucleotide polymorphismTemperament and Character InventoryComponents of the brain reward system, i.e. the mesolimbic dopamine, laterodorsal cholinergic and ghrelin signaling systems, have been implicated in alcohol reward in preclinical studies. Genetic variants ...