肠道中低浓度的Akkermansia muciniphila可能表明黏液层较薄,从而导致肠道屏障功能减弱,此外还会增加细菌毒素的易位,炎症性肠病、哮喘、肥胖症和 II 型糖尿病患者的Akkermansia muciniphila浓度往往较低。 我们知道整个胃肠道 (GI) 的粘膜完整性对于维持人体健康至关重要。这其中,粘液屏障的完整性是胃肠道的第一道防线。
肠道中低浓度的Akkermansia muciniphila可能表明黏液层较薄,从而导致肠道屏障功能减弱,此外还会增加细菌毒素的易位,炎症性肠病、哮喘、肥胖症和 II 型糖尿病患者的Akkermansia muciniphila浓度往往较低。 我们知道整个胃肠道 (GI) 的粘膜完整性对于维持人体健康至关重要。这其中,粘液屏障的完整性是胃肠道的第一道防线。
A. muciniphila如何促进粘液厚度尚不清楚。原因之一可能是A. muciniphila通过从降解的粘蛋白中制造短链脂肪酸来刺激粘液周转率,这是合成和分泌粘蛋白的宿主上皮的优选能源。事实上,A. muciniphila补充剂增加了小鼠产生粘蛋白的杯状细胞的数量。 抑制炎症 有证据表明A. muciniphila可以调节炎症。在加速衰老的小鼠模型...
Akkermansia muciniphila (A.muciniphila), an intestinal symbiont colonizing in the mucosal layer, is considered to be a promising candidate as probiotics. A.muciniphila is known to have an important value in improving the host metabolic functions and immune responses. Moreover, A.muciniphila ...
muciniphila to oxygen and animal-derived compounds in its growth medium limits its industrial application (Plovier et al., 2017). Therefore, we believe using a more convenient approach with alternative strategies is more viable. To enhance the probiotic count of A. muciniphila in vivo, the ...
2, oral supplementation of choline challenged mice with probiotic or postbiotic of A. muciniphila significantly elevated and lowered the serum levels of TG and HDL-C, respectively. The results also indicated no noticeable difference in the liver enzymes (ALT and AST) levels between the HCD and...
Akkermansia muciniphila (A. muciniphila), an intestinal symbiont colonizing in the mucosal layer, is considered to be a promising candidate as a probiotics. Most of the current researches focus on th...
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Everard, A.et al. Cross-talk betweenAkkermansia muciniphilaand intestinal epithelium controls diet-induced obesity.Proc. Natl. Acad. Sci. USA110, 9066–9071 (2013). ADSCASGoogle Scholar Derrien, M., Vaughan, E. E., Plugge, C. M. & de Vos, W. M.gen. nov., sp. nov., a human ...
In this study, the genome of Akkermansia muciniphila ONE (designated AKK ONE) was sequenced, assembled, and analyzed. In addition, the safety of this strain was further evaluated by toxicological studies. The results showed that the AKK ONE genome is contained on a single ch...