It has been reported that cancer cells utilize this glycolysis pathway even in the presence of adequate oxygen to provide cancer cells with energy, called the Warburg effect (aerobic glycolysis). Myc is known to regulate LDH and pyruvate dehydrogenase kinase 1 (PDK1), which are master regulators...
Glycolysis also facilitates routing the carbon flux into the oxidative pentose phosphate pathway (PPP), which produces NADPH for the generation of reactive oxygen species (ROS; Box 1) via NADPH oxidases. ROS production is essential for the phagocytic activity of M1 macrophages. Inhibition of ...
The "aerobic" part of aerobic cellular respiration occurs during: a) glycolysis b) the conversion of pyruvate to acetyl CoA c) the citric acid cycle d) electron transport e) All of the above are aerobic processes.What does glycolysis form u...
Mechanistically, we found that E6/E7 proteins regulate the activity of key enzymes in the aerobic glycolysis pathway by affecting the binding of IGF2BP2 to MYC m6A sites. We further established that the overexpression of IGF2BP2 in E6/E7-knockout CC cells rescued glycolytic flux. Combined, ...
Aerobic respiration follows a catabolic pathway because it breaks down a larger molecule into smaller products. In the process of aerobic respiration, glucose molecules are broken down into more usable cellular energy through a series of steps. There are four large steps to the process: Glycolysis ...
It has been reported that cancer cells utilize this glycolysis pathway even in the presence of adequate oxygen to provide cancer cells with energy, called the Warburg effect (aerobic glycolysis). Myc is known to regulate LDH and pyruvate dehydrogenase kinase 1 (PDK1), which are master regulators...
found that the upregulation of the aerobic glycolysis pathway contributes to the acquired resistance of sorafenib in HCC [23, 24]. The findings of our study have provided evidence for the association between EGR1 downregulation and the induction of aerobic glycolysis. In order to explore the ...
we demonstrated that neuronal somata perform higher levels of aerobic glycolysis and lower levels of OXPHOS than terminals, both during basal and activated states. We found that the glycolytic enzyme pyruvate kinase 2 (PKM2) is localized predominantly in the somata rather than in the terminals. Dele...
aerobic glycolysis level, which was through the stabilization of HIF-1α [104,105]. On the contrary, emerging evidence suggested that AMPK can protect cancer cells from metabolic stress to promote tumor progression [106]. Furthermore, it has been found that the activation of AMPK/mTOR pathway ...
In this work, we demonstrated that albendazole, a first-line broad-spectrum anthelmintic drug, effectively attenuated fibroblast to myofibroblast transition through alleviating TGF-β1-induced aerobic glycolysis dependent on the LRRN3/PFKFB3 signaling pathway. Additionally, LRRN3 expression was downregulated...