A dose response study using TAK-243 showed a dose-dependent activation of the reporter in each of the human PDAC cell lines including a mouse PDAC line, KPC2. In each of the three cell lines, concentrations as low as 100 nM TAK-243 were able to induce detectable levels of apoptotic ...
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Emerging antimicrobial resistance (AMR) is a leading public health concern worldwide1. Multiple studies have reported a strong association of antimicrobial usage (AMU) in animals with the extensive AMR burden2,3. Colistin (polymyxin E) has been used worldwide in food animals for decades for thera...
in this study. Wholegenome sequencing (WGS) was performed on 20 carbapenemase-producing strains, including 17 NDM-1-producingKlebsiella pneumoniaeST11-KL105 lineage strains, one NDM-1-producingEscherichia coliST58 strain and one KPC-3-producingK. pneumoniaeST147 strain, recovered from a total of ...
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(2018) reported the discovery of SDSS J103024.95 + + 551622.7, a radio-loud narrow-line Seyfert 1 galaxy having a \\sim 100 \\sim 100 kpc scale double-lobed radio structure. Here we analyse archival radio interferometric imaging data taken with the Very Large Array (VLA) at 5 GHz, and...
[492Star][29d] [Rust] kpcyrd/sn0int Semi-automatic OSINT framework and package manager [475Star][4m] [Py] xillwillx/skiptracer OSINT python webscaping framework [442Star][3m] [Py] superhedgy/attacksurfacemapper AttackSurfaceMapper is a tool that aims to automate the reco...
or are probably misidentified (Q 0230+3429, B2 0937+26, MS 2347.4+1924).Restricting ourselves to the 11 BL Lac objects ( z = 0.6), where a core and host galaxy was detected, we find that their host galaxies are luminous (MI = -25.2 ± 0.8) and large (re = 10.5 ± 7 kpc). Th...
have reported that inhibition of Hedgehog signaling enhanced the delivery of gemcitabine chemotherapy in a KPC rodent model of pancreatic ductal adenocarcinoma [170]. Collectively, it was proposed that if a drug could halt the process of EMT, it might also overcome chemoresistance...