The prevalence of kidney diseases is emerging as a public health problem. Stem cells (SCs), currently considered as a promising tool for therapeutic application, have aroused considerable interest and expectations. With self-renewal capabilities and grea
Treatment of idiopathic FSGS commonly involves immune-based and nonimmunologic therapy options. This manuscript will review the current state of FSGS therapy for children.doi:10.1053/j.ackd.2014.01.010Christine B SethnaDebbie S GipsonElsevier Inc.Adv Chronic Kidney Dis...
Common Blood Tests for Kidney PatientsNephrotic SyndromeIntroduction and Causes Nephrotic syndrome is a common kidney disease characterized by heavy loss of protein in urine, low blood protein levels, high cholesterol levels and swelling. This disease can occur at any age but is seen more frequently...
Integrins are essential for organ development, homeostasis, and the progression of kidney disease [35]. The activation of integrin αvβ3 on podocytes is documented in the pathogenesis of proteinuric kidney diseases such as FSGS and DN [36]. Blocking integrin αvβ3 activation by antagonist trea...
EET Analogs and the Dual‐Inhibition of sEH/COX‐2 for the Treatment of Focal Segmental Glomerular SclerosisFocal segmental glomerulosclerosis (FSGS) is the single most common form of kidney disease. This devastating disorder can lead to end stage renal disease (ESRD), a terminal diagnosis in the...
[21]. Recent research, as indicated in Table2, underscores the practicality of urinary exosomal mRNA as biomarkers for various kidney diseases, including IMN, DN, FSGS, IgA nephropathy, renal fibrosis, and CKD. For example, in IMN patients, CCL2 mRNA expression was significantly elevated ...
Minimal change disease (MCD) is a major cause of nephrotic syndrome (approximately 90 percent) in children and in a minority of adults (approximately 10 percent). MCD and focal segmental glomerulosclerosis (FSGS) are both examples of pathogenic mechanisms that primarily affect the podocyte ("podocy...
FSGS can also be caused by a virus (such as HIV), medications, genetic mutations, obesity, high blood pressure and vascular disease, and many others Membranous nephropathy, in which the membranes of the glomeruli thicken. PLA2R antibodies cause the majority of primary membranous nephropathies. ...
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20, ITSN1, ITSN2) as causing NS in 17 families with partially treatment-sensitive
Focal segmental glomerulosclerosis (FSGS), IgA nephropathy (i.e., Berger's disease), IgM nephropathy, Membranoproliferative glomerulonephritis, Membranous nephropathy, Minimal change disease, Hypertensive nephrosclerosis and Interstitial nephritis. In a certain embodiment of the invention the kidney proteinuri...