CD36是Thbs1抑制脂肪生成和肝细胞内过量甘油三酯储存作用所必需的,表明CD36是Thbs1抑制肝脂肪生成药理作用所必需的。尽管这些结果似乎与先前显示CD36缺陷小鼠脂肪生成基因表达降低的研究相矛盾[43],但CD36信号可能被不同激活,以增加或减少肝脏脂肪生成,从而响应不同的细胞配体或环境刺激。可以想象,肝脏脂肪含量可能由精...
Also, THBS1 was observed to interact with CD36, a membrane signal receptor and activator of the cAMP signaling pathway, to regulate the fusion of cytotrophoblast cells. Overexpression of THBS1 inhibited the cAMP signaling pathway and reduced the BeWo cells fusion ratio, while the effects of THB...
alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, ?v...
THBS1 以其多受体结合而闻名,包括整合素和 CD36,调节与细胞粘附、迁移和存活相关的信号通路。THBS1 Protein, Mouse (His) 是重组的 THBS1 蛋白,由 E. coli 表达,带有 N-6*His 标签。THBS1 Protein, Mouse (His) 全长 332 个氨基酸,分子量为 40.6 kDa。 品牌介绍: MCE (MedChemExpress) 拥有数百种...
TSP-1是1971年由Baenziger等首次从血小板细胞膜中分离,由正常的纤维细胞、内皮细胞、平滑肌细胞、脑胶质细胞及膀胱上皮细胞等分泌,作用于膜受体CD36,并活化Fyn、Src酪氨酸激酶,内皮细胞。 |特异性 可检测样本中大鼠的THBS1,且与其类似物无明显交叉反应。
although the extent of the increase was less than that in tumors inThbs1-/-mice (Fig.4b, c). Reflecting the difference in CD8+T cell infiltration, MTO-bearingCd47-/-andCd36-/-mice showed reduced liver metastases, although to a slightly lesser extent than MTO-bearingThbs1-/-mice (Fig....
摘要:近年来,在多种类型的肿瘤中均发现了血小板凝血酶蛋白Ｇ１(t h r o m b o s p o n d i n Ｇ１,T H B S １)的异常表达,其是近年来肿瘤领域研究的热门靶点基因.T H B S １作为一种多功能蛋白,在肿瘤中的作用较为复杂,对肿瘤的影响机制尚不完全明确,功能及调控机制有待进一步深入研究.现对...
MiR-24 promotes cell growth in human glioma by CDX1/PI3K/Akt signaling pathway. Cancer Biother Radiopharm. 2021;36(7):588–99. 17. Han Y, Wang H. MiR-3918 inhibits tumorigenesis of Glioma via Targeting EGFR to regulate PI3K/AKT and ERK pathways. J Mol Neuroscience: MN. 2022;72(2):...
Based on other surveys, both CD36 and CD47 are required for OC differentiation and maturation and more interestingly, anti-THBS-1 antibodies completely suppress the differentiation of these cells. However, L-NAME treatment has been shown to rescue this inhibitory effect20. Based on the above-...
THBS1与淋巴管生长也有一定关系,其与单核细胞表面CD36结合后可抑制炎症诱导的淋巴管生长,并明显抑制淋巴管内皮细胞增殖和游走[15]。THBS4由于缺少TSRs序列,其抑制血管生成的作用较THBS1弱。研究表明,THBS4表达与MMP9表达密切相关,可促进肿瘤侵袭转移[16]。本研究免疫组化染色结果显示,THBS1和THBS4表达定位于细胞...