Gene Type protein-coding gene Uniprot ID P01137 Pathway/Library Diabetes Related Genes Library; Cell Proliferation Related Genes Library; Cell Cycle Pathway Genes Library; Tumor Invasion Related Genes Library Gene Summary TGFB is a multifunctional peptide that controls proliferation, differentiation, and ...
Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Ar
The function of transforming growth factor β1 in myocardial protection and remodeling from ischemia-reperfusion injury; 转化生长因子β1在心肌缺氧缺血再灌注损伤修复及心肌重塑中的作用 2. The mechanism of growth inhibition by transforming growth factor β1 (TGF-β1) on esophageal carcinoma cell in ...
Recombinant Mouse Transforming Growth Factor beta 1 is produced by our Mammalian expression system and the target gene encoding Ala279-Ser390 is expressed. Accession: P04202 中文别名: TGFβ1蛋白; TGFB1蛋白 来源: Human Cells 纯度: Greater than 95% as determined by reducing SDS-PAGE. ...
intensity, as well as normal pulmonary function, were determined for three previously associated TGFB1 single nucleotide polymorphisms (SNPs), -10807G/A (rs2241712) and -509T/C (rs1800469), located in or near the promoter, and 29T/C (rs1982073), located in exon 1 of the TGFB1 gene. ...
TGF-β1 also has immunomodulatory functions, influencing the differentiation and function of immune cells. However, dysregulation of TGF-β1 signaling is associated with various pathologies, including cancer progression, fibrosis, and autoimmune disorders. Role in Cancer: TGF-β1 acts as a tumor ...
expressionofamiRNA-targettumorsuppressorgeneand663werenormalizedbytheaverageofthecontrolsamples. leadtocancerprogression(Osadaetal.,2007). Transfection Inthepresentstudy,welookedforalterationsofA549cellswereplatedatadensityof5×105cellsperwellin6-well miR-663intenpatientswithlungcancer.Weherehaveplates.Transfection...
The sensitivity of tumor cells to TGF-b is likely influenced by genetic alterations, such as gene mutations or deletion of the TGF-b receptor gene, and may also be influenced by cell cycle status. Cell differentiation, migration, or apoptosis in response to TGF-b during early embryogenesis ...
Together, these data suggest that RAC1B favors synthesis and secretion of autocrine TGFβ1 which in a SMAD3-dependent manner blocks EMT-associated gene expression and cell motility. Keywords: RAC1B; transforming growth factor β; pancreatic cancer; breast cancer; cell migration; autocrine ...
In contrast to these negative regulatory effects of TGF-β1 on function and maturation of lymphoid tissue type DCs, certain subpopulations of immature DCs in nonlymphoid tissues are positively regulated by TGF-β1 signaling. In particular, epithelial-associated DC populations seem to critically ...