doi:10.1002/9780470015902.a0022525Esben PedersenCord BrakebuschJohn Wiley & Sons, LtdPedersen E, Brakebusch C (2010) Rho GTPase Function in Cell Morphogenesis. eLS publication. London, U.K.: John Wiley & Sons, Ltd.
Rho 型鸟嘌呤核苷酸交换因子(RhoGEF) 是调节Rho GTPase 活性的关键因子,在Rho GTPase 信号调节、组织器官#br#的生长发育及免疫应答中起着至关重要的作用。RhoGEF 与肿瘤、发育及神经类疾病、病原微生物感染等也有密切关系,对其功能#br#的深入了解有助于人们认识某些生理和病理现象的发生机制。 关键词: Rho ...
neuralsystemrelateddiseasesandpathogeninfection,understandingofitsfunctionwillhelpustoverifythemechanismsofsomephysiologicalandpathologicalprocess.Keywords:RhoGTPaseGuaninenucleotideexchangefactors(GEFs)Diseaseoccurrence在真核生物中,普遍存在着一种能够与三磷酸鸟苷(GTP)结合的蛋白家族,我们称之为小G蛋白家族(smallGTPase...
作为一种慢性、遗传性的视网膜退行性病变，RP相关的致病基因就有近百个，包括视紫红质（Rhodopsin, RHO）、Usher综合征2A（Usher syndrome 2A, USH2A）和视网膜色素变性GTP酶调控因子（Retinitis pigmentosa gtpase regulator, RPGR）等。其中，RHO合成的视紫红质与视觉电信号产生密切相关，该基因导致了约25％的显性RP...
作为一种慢性、遗传性的视网膜退行性病变,RP相关的致病基因就有近百个,包括视紫红质(Rhodopsin, RHO)、Usher综合征2A(Usher syndrome 2A, USH2A)和视网膜色素变性GTP酶调控因子(Retinitis pigmentosa gtpase regulator, RPGR)等。需要复习的小伙伴看这里~
Control of Rho GTPase function by BAR- domains. Small GTPases 3, 45-52.de Kreuk BJ, Hordijk PL (2012) Control of Rho GTPase function by BAR-domains. Small GTPases 3(1): 45- 52de Kreuk, B. J., and Hordijk, P. L. (2012) Control of Rho GTPase function by BAR- domains. ...
RAC and CDC42. GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and othe...
( 1) 鸟苷酸交换因子(guanine nucleotide exchange factors GEFs):调控小蛋白GDP/GTP的转换,GTP通过其端与特异性靶区作用而定位于胞膜,(2)GT P酶激活蛋白(GTPase activating protein s,GA P s),提高Rho GTPase的内在GTP酶活性,加速GTP酶的水解,使R ho蛋白恢复到GDP结合的失活状态;(3)GDP解离抑制因子(GDP ...
www.nature.com/scientificreports OPEN received: 13 July 2016 accepted: 21 October 2016 Published: 14 November 2016 Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα Silvia Pasini*,†, Jin Liu*, Carlo Corona, Eugenie Peze-...
Nevertheless, FTIs have exhibited anti-tumor activity in preclinical and clinical trial analyses, presumably due to the inhibition of function of other FTase substrates (8). In light of the role of aberrant Rho GTPase function in oncogenesis, Rho family GTPases (e.g. RhoB) are logical ...