Full size image These two assays displayed generally consistent ACE2 usage patterns, with a few exceptions. These apparent discrepancies in two different assays are commonly observed when testing other coronaviruses. Except for the RBD concentrations or viral titer/infectivities that may result in dif...
RBDCoV-ACE2 has limitations similar to other protein-based in vitro neutralization assays, such as only accounting for the Nabs that block the RBD-ACE2 interaction site through steric hindrance, and not for Nabs that interfere with cell entry mechanisms as would be analyzed in a VNT. Furthermo...