对感染性细菌来说,Rac1是一个特别有吸引力的目标。 睡眠嗜血杆菌和副溶血性弧菌分别介导氨基酸残基Tyr32和Thr35的ampyulation。 ampyation通过阻止与下游效应物的相互作用导致GTPase活性失活,从而抑制肌动蛋白介导的感染细胞过程。 毒素PAU_02230来自Photorhabdus asymbiotica glycosylates (mono-O-GlcNAcylation) Rac1...
[61,62]. To understand how Rac1b may differ in function from Rac1, biochemical techniques were used to assess the ability of each protein to bind GTP. When compared to Rac1, Rac1b was found to have accelerated GTP exchange rates, thus Rac1b acts like a fast cycling GTPase[62]. The...
【关键词】 Rac;T淋巴细胞;发育;活化;迁移【中图分类号】 R329.26RoleofRacProteinsintheDevelopmentandFunctionofTLympho-cytesZHANGLu,CHENWeiInstituteofImmunology,ZhejiangUniversity,Hangzhou,310058,China【Abstract】 TheRacGTPasesareagroupofkeymoleculesforcellularsignalingtransduc tion.Bothpre TCRandTCRsignals...
Three of the 4 vertebrate Rac-related genes, namely Rac1, Rac3 and RhoG, are expressed in the nervous system, and several data support an essential role of all 3 GTPases in distinct aspects of neuronal development and function. Two important points emerge from the analysis presented: highly...
EHop-016是一种新型的RAC GTPase小分子抑制剂,图8a所示,EHop-016能抑制肺癌细胞增殖,且其在三种细胞系中的用量有所不同(图8b)。因此作者检测了EHop-016对RAC1活性的影响,结果显示,EHop-016可降低RAC1-GTP的表达(图8c),而LCAT1敲除则使细胞对EHop-016失去敏感性(图8 d)。紫杉醇是一种广泛用于治疗包括肺癌...
Rac1在各种肿瘤中过度表达或突变,Rac1的gain-of-function (GOF) 突变可导致癌症相关表型。 Rac1不仅参与肿瘤的形成、进展、侵袭和血管生成,还介导肿瘤细胞对放疗、化疗和免疫治疗的抵抗,抑制Rac1可以抑制肿瘤生长并恢复患者对癌症治疗的敏感性。 研究Rac1...
The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (RO
Axons navigate the extracellular environment by responding to guidance cues that bind to cell surface receptors to relay information intracellularly via Rho GTPase family members, including the Rac GTPases.Steffen NφrgaardDevelopment and Stem Cells ProgramRoger PocockBiotech Research and Innovation Centre...
We aimed to investigate the expression and clinic significance of Rac GTPase Activating Protein 1 (RACGAP1) in human lung adenocarcinoma (LUAD). Online database analysis revealed a significant increase in RACGAP1 mRNA expression among 26 types of tumor tissues, including LUAD tissues. Online data...
Function : Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization ...