在肿瘤发生过程中，铁死亡具有促进和抑制肿瘤的双重作用，这依赖于肿瘤微环境中损伤相关分子模式（damage- ...
前列腺素内过氧化物合酶(PTGS),又称环加氧酶,是前列腺素生物合成中的关键酶,既是一种双加氧酶又是一种过氧化物酶。PTGS有两种同工酶:组成型PTGS1和诱导型PTGS2,它们在表达和组织分布的调节上存在差异。这个基因编码诱导同工酶。它由特定的刺激事件调节,提示它与炎症
相关研究结果近期发表在Cancer Cell期刊上，论文标题为“CD8+ T cells and fatty acids orchestrate tumor...
M,et al. Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians:a case-control study. BMC cancer,2010. 10:613. [13]许东奎,张雪梅,赵平等. COX-2基因启动子区单核苷酸多态与肝癌遗传易感性的关系.中华肝胆外科杂志,2009. 14(12):840-843. [14]Chang,W....
Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case–control studies. Carcinogenesis, 29, 568-72.Danforth, K. N., Hayes, R. B., Rodriguez, C., Yu, K., Sakoda, L. C., Huang, W. Y., Chen, B. E., Chen, J., Andriole, G. L., Calle, ...
PTGS2-positive patients were at an increased risk of tumor recurrence (n = 9 studies; HR, 2.79; 95% CI, 1.76-4.41; P Conclusions: PTGS2 expression was associated with an increased risk of tumor recurrence and poorer colorectal cancer-specific survival but not overall survival among patients ...
PTGS2–899G>C and prostate cancer risk: a population-based nested case–control study (ProtecT) and a systematic review with meta-analysis. 来自 EBSCO 喜欢 0 阅读量: 20 摘要: Prostaglandin endoperoxidase synthase 2 is a key regulator of inflammation and may play a role in prostate ...
Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and pr...
COX-2 as a target for cancer chemotherapy. Pharmacological reports, 2010, 62(2): 233-244. 5. Murakami M, Kudo I. Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prostaglandins & other lipid mediators, 2004, 68-69: 99-122....
Schafer - 《Current Cancer Drug Targets》 被引量: 52发表: 2010年 Sarcoidosis and interstitial pulmonary fibrosis; two distinct disorders or two ends of the same spectrum Another study found a promoter polymorphism in prostaglandin-endoperoxide synthase 2 (PTGS2), -765G>C, to be associated with...