thienopyhmidine compounds of general formula (I), pharmaceutical compositions comprising these compounds and their therapeutic use for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or ...
【题目】一位同学拿了两块45°三角尺△MNK,△ACB做了一个探究活动:将△MNK的直角顶点M放在△ABC的斜边AB的中点处,设AC=BC=4.AAANMMMNBBBCG
摘要 本发明提供了一种抑制MNK1和MNK2的多环化合物,具体地,本发明提供了一种式(I)所示的化合物:或其立体异构体、互变异构体或药学上可接受的盐,其中,各基团的定义如说明书所述。本发明的化合物可以用于制备治疗MNK活性或表达量相关的疾病或病症的药物组合物。 摘要附图 新闻...
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ISOINDOLINE, AZAISOINDOLINE, DIHYDROINDENONE AND DIHYDROAZAINDENONE INHIBITORS OF MNK1 AND MNK2The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof.Paul A...