Last week, you might have read about carbapenem-resistant ‘superbugs’ (actually, these are pretty ordinary bacteria except that they’re resistant to just about everything we can throw at them) due to the recent study detailing an outbreak at the NIH. I’ve … Continue reading → Posted ...
The most common mechanism of resistance to β-lactam antibiotics in Gram-negative bacteria is the production of β-lactamases. There are four classes of β-lactamases (A, B, C, D) based on the primary amino acid sequence homology (8). Classes A, C, and D are serine hydrolases, whereas...
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis. 2009;9(4):228–36. https://doi.org/10.1016/S1473-3099(09)70054-4. Article CAS PubMed Google Scholar Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1,...
中国现代医药杂志2016年1月第18卷 1期MMJC,Jan2 6,Vol 8,No. 为了对抗产超广谱β内酰胺酶(Extended-Spec鄄trumβ-Lactamases,ESBLs)细菌的耐药性,碳青霉烯类 菌药物被大量应用,而这又引起 霉烯类耐药细菌在全球的 生与流行[1]。肠杆菌科细菌作为医院感染最主要的病原体类型,其对 霉烯类 素的耐药给全球...
The emergence of Klebsiella pneumoniae carbapenemases (KPCs) producing bacteria has become a significant global public health challenge while the optimal treatment remains undefined. We performed a systematic review of published studies and reports of treatment outcomes of KPC infections using MEDLINE (2001...
Timely microbiological diagnosis and optimizing antibiotic dosing regimens are essential to prevent worse outcomes. Further studies and well-controlled clinical trials are needed to define the optimal treatment of infections by KPC-Kp and, more generally, carbapenem-resistant bacteria....
OutbreakWhole-genome sequencing (WGS)Objectives: Whole-genome sequencing (WGS) is a promising tool for identifying transmission pathways in outbreaks caused by multidrug-resistant bacteria. However, it is uncertain how the data produced by WGS can be best integrated into epidemiologic investigations....
pneumoniae genomes (MGH 78578, NTUH-K2044 and 342), to gain insights into the resistance and virulence repertoire of this strain, its unique/shared gene content relative to the compared strains and plasticity regions that may be circulating in other clinically relevant bacteria. Results and ...
The following data were collected: site of KPC-KP culture; present or past history of cultures positive with other MDROs, including vancomycin-resistant enterococci, ESBL-producing Gram-negative bacteria and methicillin-resistant Staphylococcus aureus; and microbiological response to therapy. The presence ...
(CRKP).Understanding the resistance mechanism and infection status of CRKP antibacterial to carbopenems.Provide the basis for the clinical anti infection treatment and hospital infection control.Methods The application of BD phoenixTM-100 automatic bacteria identification and drug sensitivity analysis system...