Pediatric neurotoxicity Studies conducted in young animals and children suggest repeated or prolonged use of general anesthetic or sedation drugs in children younger than 3 years may have negative effects on their developing brains. Discuss with parents and caregivers the benefits, risks, timing, and ...
The behavioral pharmacological effects of ketamine in animals have been reviewed. Ketamine does not cause remarkable behavioral changes at doses effective for the treatment of depressive behavior in animal models. However, a transient increase in spontaneous motor activity has been reported sometimes. ...
There is ongoing research into the drug's usefulness in pain therapy and for the treatment of alcoholism and heroin addiction. In veterinary medicine, ketamine is often used for its anaesthetic and analgesic effects on cats, dogs, rabbits, rats, and other small animals. Veterinarians often ...
Ketamine has been used to provide analgesia in refractory chronic pain conditions and even anesthesia for short surgeries. However, the safety data is mixed regarding its toxicity when administered neuraxial in animals, with some authors suggesting that its neurotoxicity derives from preservatives. Accordi...
Ketamine is primarily used to induce anesthesia in animals undergoing veterinary surgery. The drug produces dreamlike, paralytic effects similar to those of PCP that can last between 30 minutes and one hour. People who use ketamine experience intense highs and dissociative feelings that make users fee...
InMeyler's Side Effects of Drugs (Sixteenth Edition), 2016 Ketamine Ketamineis extensively metabolized. In a placebo-controlled study in 11 healthy volunteers, who were given intravenous S-ketamine 0.1mg/kg or oral ketamine 0.3mg/kg, rifampicin reduced the mean AUC of intravenous and oral ketamin...
chlorpromazine (central depressant and peripheral α-adrenergic blockade), by β-adrenergic blockade, and by ganglionic blockade. The tachycardia and increase in myocardial contractile force seen in intact animals does not appear in isolated hearts (Langendorff) at a concentration of 0.1 mg of ...
chlorpromazine (central depressant and peripheral α-adrenergic blockade), by β-adrenergic blockade, and by ganglionic blockade. The tachycardia and increase in myocardial contractile force seen in intact animals does not appear in isolated hearts (Langendorff) at a concentration of 0.1 mg of ...
Most remarkably, this cascade of processes results in the rapid proliferation of dendritic spines that share a temporal profile with antidepressant effects. As illustrated in Figure 1D, these effects in animals are paralleled by restoration of functional connectivity in an fMRI study of depressed ...
However, SNC80 and dextromethorphan did not produce a complete block of responses in all animals at any of the doses tested. At the highest dose tested, 80 mg/kg, dextromethorphan Discussion Although many previous studies have investigated interactions of NMDA antagonists with opioids, they have ...