promotes tumor cell invasion and metastasis by activating rhoa/rock signaling pathway. inhibits cdh1-mediated cell adhesion in process independent from rho activation。 图像: immunohistochemistry of paraffin-embedded human stomach using fnab10935(gna13 antibody) at dilution of 1:100。 various lysates ...
This Gα12/13-RhoA signaling has been implicated in the process of invasion and metastasis in multiple cancer models including those of breast (particularly TNBC), ovarian and prostate [15,16,17,18,19]. Further, Gα13 has also been shown to play a role in promoting cell proliferation [20...
Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, et al. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Galpha13/RhoA axis in B...
深入测序研究发现,RhoA频繁突变于伯基特(Burkitt)淋巴瘤,而GNA13和S1PR2突变主要见于生发中心B细胞来源的弥漫大B细胞淋巴瘤(germinal center B cell-like diffuse large B-cell lymphoma, GCB-DLBCL)[25]。 2014年,Muppidi等进行体内体外实验发现,GCB-DLBCL相关的S1PR2突变会频繁破坏受体AKT信号转导通路和迁移抑制...
Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). [UniProt] 仅用于科研。不用于诊断过程。未经明确授权不得转售。
Figure S2. microRNA-31 did not impact RhoA-3′-UTR: (A) Reporter assays performed in MCF-10a cells transfected with antimiR-control or antimiR-31. (B) Reporter assays performed in MDA-MB-231 cells transfected with premiR-control or premiR-31. All reporter assays results are reported ...