GHB (gamma hydroxybutyrate) was developed as a general anesthetic. Due to dosing difficulty and side effects, regular use was discontinued. Medical uses include treating sleep and alcohol disorders. In the 1990s, it was promoted as a supplement and taken to improve mood and sex. GHB and its ...
Overview Uses Side Effects Precautions Interactions Dosing Reviews (6) Overview Gamma butyrolactone (GBL) is a chemical in cleaning solutions and nail polish. In the body, GBL is converted to gamma-hydroxybutyrate (GHB), a date-rape drug. When the body converts GBL into GHB, it can turn ...
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γ-Hydroxybutyrate (GHB) is a short-chain fatty acid that occurs naturally in the human brain and acts as a neurotransmitter and neuromodulator [1]. GHB was developed in the 1960s as an anaesthetic agent [2], but its use in anaesthesia remained limited due to inadequate analgesia, the ...
γ-Hydroxybutyrate, γ-Butyrolactone GBH is an odorless and colorless liquid with a slightly salty taste used as a club drug. The precursor chemicals used in the manufacture of GHB, γ-butyrolactone and 1,4-butanediol, have been used to the same effect under the same circumstances. ...
关键词: Gamma-hydroxybutyrate Gamma-hydroxybutyric acid Alcohol withdrawal syndrome Craving Gamma-hydroxybutyric acid diversion DOI: 10.1016/S0741-8329(99)00093-2 被引量: 57 年份: 2000 收藏 引用 批量引用 报错 分享 全部来源 求助全文 全文购买 Elsevier dx.doi.org Ingenta NCBI NCBI 查看更多 相似文献...
Regulation of glucagon secretion in normal and diabetic human islets by gamma-hydroxybutyrate and glycine. J. Biol. Chem. 288, 3938–3951 (2013). Article CAS Google Scholar Alam, S., Laughton, D. L., Walding, A. & Wolstenholme, A. J. Human peripheral blood mononuclear cells express ...
GHB is naturally produced in the human body's cells and is structurally related to the ketone body beta-hydroxybutyrate. As a drug, it is used most commonly in the form of a salt. [4] GHB is also produced as a result of fermentation, and so is found in small quantities in some ...
Bedard, M. A., “Nocturnal y-Hydroxybutyrate—Effect on Periodic Leg Movements and Sleep Organization of Narcoleptic Patients”, Clin Neuropharmacol. 12(1), (1989), 29-36. Broughton, R., et al., “Effects of nocturnal gamma-hydroxybutyrate on sleep/waking patterns in narcolepsy-cataplexy”, ...