CD46: expanding beyond com- ** plement regulation. Trends Immunol 2004; 25:496-503. The article describes the expression pattern, function, and signaling that this com- plement regulating protein participates in, and the diseases, especially HUS, which occur in the context of its deficiency....
the A exon is rarely used) to the B exon and the cytoplasmic tail to either Cyt-1 or Cyt-2 gives rise to four majorisoformsof CD46 called C1, C2, BC1 and BC2. N-glycans in SCRs 2 and 4 are required for cofactor activity. The STP region modulates CD46 function. For example, the...
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CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner ...
In mammals, CD46 is involved in the inactivation of complement by factor I (FI). In teleost, study on the function of CD46 is very limited. In this study, we examined the immunological property of a CD46 molecule (CsCD46) from tongue sole, a teleost spec
CD46 is expressed on the majority of nucleated cells, and functions as a regulator of complement function by binding complement components C3b and C4b, which serves to protect the host from autologous complement attack. CD46 has been called a "pathogen magnet" as it is known to play a role...
A functionnal mapping of the protein domains involved in the interaction between CD46 and the virus envelope glycoproteins hemagglutinin (H) and fusion protein (F) is partly available. The corresponding data lead to propose a dynamic model of the two steps of the virus entry, attachement and ...
We establish herein that cell contact-mediated nTreg regulatory function is inhibited by inflammation, especially in the presence of the complement C3b receptor (CD46). Instead, as with other T-cell subsets, the latter inflammatory conditions of stimulation skew nTreg differentiation to Tr1 cells ...
GPI锚固型CD46/CD55、CD46/CD55/CD59嵌合 分子的设计及克隆载体的构建 摘要 补体是机体的一个重要的天然防御系统。然而大量研究表明,补体过 度活化可以造成自身组织细胞的损伤。通过阻断补体活化来治疗补体介导 的炎症损伤已经成为国内外医学家共同关注的课题。随常情况下,补体系 统的活化由血浆及细胞膜表面的补体调...
CD46 is a ubiquitously expressed type I membrane-bound protein with a main function of protecting human host cells from complement (1). CD46 exerts such function by acting as a cofactor for Factor I-mediated cleavage of C3b and C4b (1). In addition, CD46 acts as a co-stimulator of T...