The same concern is often raised regarding the benchmark dose (BMD) method (Crump, 1984), which requires setting of a benchmark risk (BMR) in order to estimate the lower confidence limit of the benchmark dose (BMDL) (Crump, 1995). A Validated Algorithm for Selecting Non-Toxic Chemical Co...
Variation in benchmark dose (BMD) and the 95% lower confidence limit of benchmark dose (BMDL) among general Japanese populations with no anthropogenic exposure to cadmium. Int Arch Occup Environ Health, 2012; 85, 941-50.Sakuragi S,Takahashi K,Hoshuyama T,et al.Variation in benchmark dose(...
Key words:3-MCPD and its esters;benchmark dose(BMD);Bayesian model averaging 氯丙醇酯是含脂食物在热加工过程中 ,尤其是在油脂精炼过程中形成的一类新型污染物 ,其中 3- 氯 -1,2- 丙二醇脂肪酸酯(简称 3- 氯丙醇酯 ,3- Monochloro-1,2-propanediol ester,3-MCPD 酯)的污染水平最高[1]. 国内外...
(BenchmarkDoseApproach)来代替NOAEL法[1].基准剂量(BenchmarkDose,BMD)是指某一指定的低水平剂量反应时的剂量,此时的剂量反应称为基准剂量反应(BenchmarkResponse,BMR),一般采用基准剂量的可信限下限(Benchmarkdoselowerconfidencelimit,BMDL)来替代NOAEL【.本文采用基准剂量法和NOAEL法对除草剂特丁净亚慢性毒性进行分析,...
Although benchmark-dose methodology has existed for more than 20 years, benchmark doses (BMDs) still have not fully supplanted the no-observed-adverse-effect level (NOAEL) and lowest-observed-adverse-effect level (LOAEL) as points of departure from the experimental doseresponse range for setting...
Although benchmark-dose methodology has existed for more than 20 years, benchmark doses (BMDs) still have not fully supplanted the no-observed-adverse-effect level (NOAEL) and lowest-observed-adverse-effect level (LOAEL) as points of departure from the experimental doseresponse range for setting...
为与定性反应变量中的BMR和BMD区别，我们将定量的反应变量定义为临界效应大小(critical effect size，CES)，与其相关的剂量被称为临界效应剂量(critical effect dose，CED)。应用 对于特定化学物，每一个体会有自己的CED值，即CED的敏感性会在人群间存在变异性，被称作individual CED(ICED)，同时每一个体会有自身的...