In vitro and mouse studies identified a BDK inhibitor that could help treat diseases associated with accumulation of branched-chain amino acids (BCAAs), including the genetic disorder branched-chain ketoaciduria, obesity and diabetes. Further details on the research, next steps and licensing status ...
2d). To further confirm these results, 3,6-dichlorobrenzo(b)thiophene-2-carboxylic acid (BT2), a small-molecule inhibitor of BCKDK [10, 38], was employed to determine the role of BCKDK in CRC. HCT116 and SW620 cells were treated with various concentrations of BT2 for 24 or 48 h...
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Notably, the small-molecule inhibitor of BCKDK, 3,6-dichlorobenzo(b)thiophene-2-carboxylic acid, exhibited anti-tumour effects in a patient-derived tumour xenograft model. Our findings hold significant promise for developing targeted therapies aimed at disrupting the MAZ/BCKDK/G6PD signalling pathway,...
Zixia YangChenrui ZhangJinping LiZheng FuCell Death & DiseaseZhang X, Fang H, Zhang J, Yuan Y, Xu W (2011) Recent advances in aminopeptidase N (APN/CD13) inhibitor research. Curr Med Chem 18:5011–5021. : 10.2174/092986711797535155